Why and where is the Zika virus causing alarm?

Global health officials are racing to better understand the Zika virus behind a major outbreak that began in Brazil last year and has spread to many countries in the Americas.

The following are some questions and answers about the virus and current outbreak:

How do people become infected?

Zika is transmitted to people through the bite of infected female mosquitoes, primarily the Aedes aegypti mosquito, the same type that spreads dengue, chikungunya and yellow fever. The Pan American Health Organization (PAHO) said Aedes mosquitoes are found in all countries in the Americas except Canada and continental Chile, and the virus will likely reach all countries and territories of the region where Aedes mosquitoes are found.

How do you treat Zika?

There is no treatment or vaccine for Zika infection. Companies and scientists are racing to develop a safe and effective vaccine for Zika, but the World Health Organization (WHO) had said it would take at least 18 months to start large-scale clinical trials of potential preventative shots.

How dangerous is it?

The U.S. Centers for Disease Control and Prevention concluded that infection with the Zika virus in pregnant women is a cause of the birth defect microcephaly and other severe brain abnormalities in babies. The CDC said now that the causal relationship has been established, several important questions must still be answered with studies that could take years.

According to the World Health Organization, there is strong scientific consensus that Zika can cause the birth defect microcephaly in babies, a condition defined by unusually small heads that can result in developmental problems. In addition, the agency said it could cause Guillain-Barre syndrome, a rare neurological disorder that can result in paralysis. Conclusive proof of the damage caused by Zika may take months or years.

Brazil has confirmed 1,113 cases of microcephaly, and considers most of them to be related to Zika infections in the mothers. Brazil is investigating an additional 3,836 suspected cases of microcephaly. Colombia has confirmed two cases of microcephaly linked to Zika.

Current research in Brazil indicates the greatest microcephaly risk is associated with infection during the first trimester of pregnancy, but health officials have warned an impact could be seen in later weeks. Recent studies have shown evidence of Zika in amniotic fluid, placenta and fetal brain tissue.

What are the symptoms of Zika infection?

People infected with Zika may have a mild fever, skin rash, conjunctivitis, muscle and joint pain and fatigue that can last for two to seven days. But as many as 80 percent of people infected never develop symptoms. The symptoms are similar to those of dengue or chikungunya, which are transmitted by the same type of mosquito.

How can Zika be contained?

Efforts to control the spread of the virus focus on eliminating mosquito breeding sites and taking precautions against mosquito bites such as using insect repellent and mosquito nets. U.S. and international health officials have advised pregnant women to avoid travel to Latin American and Caribbean countries where they may be exposed to Zika. Cases of sexual transmission have also been reported, prompting health officials to advise use of condoms, or abstaining from sex, to prevent infection between partners.

How widespread is the outbreak?

Active Zika outbreaks have been reported in at least 42 countries or territories, most of them in the Americas, according to the U.S. Centers for Disease Control and Prevention (CDC). Brazil has been the country most affected. (http://1.usa.gov/1ovAJyh)

Africa (1): Cape Verde

Americas (34): Aruba, Barbados, Bolivia, Bonaire, Brazil, Colombia, Costa Rica, Cuba, Curaçao, Dominica, Dominican Republic, Ecuador, El Salvador, French Guiana, Guadeloupe, Guatemala, Guyana, Haiti, Honduras, Jamaica, Martinique, Mexico, Nicaragua, Panama, Paraguay, Puerto Rico, Saint Lucia, Saint Martin, Saint Vincent and the Grenadines, St. Maarten, Suriname, Trinidad and Tobago, U.S. Virgin Islands and Venezuela

Oceania/Pacific Islands (7): American Samoa, Fiji, Kosrae, Federated States of Micronesia, Marshall Islands, New Caledonia, Samoa, and Tonga.

What is the history of the Zika virus?

The Zika virus is found in tropical locales with large mosquito populations. Outbreaks of Zika have been recorded in Africa, the Americas, Southern Asia and the Western Pacific. The virus was first identified in Uganda in 1947 in rhesus monkeys and was first identified in people in 1952 in Uganda and Tanzania, according to the WHO.

Can Zika be transmitted through sexual contact?

The World Health Organization (WHO) said sexual transmission is "relatively common" and has advised pregnant women not to travel to areas with ongoing outbreaks of Zika virus.

The U.S. CDC is investigating about a dozen cases of possible sexual transmission. All cases involve possible transmission of the virus from men to their sex partners. The WHO has also identified Zika cases in Argentina, Chile, France, Italy and New Zealand as likely caused by sexual transmission.

British health officials reported Zika was found in a man's semen two months after he was infected, suggesting the virus may linger in semen long after infection symptoms fade.

The PAHO said Zika can be transmitted through blood, but this is an infrequent transmission mechanism. There is no evidence Zika can be transmitted to babies through breast milk.

What other complications are associated with Zika?

Zika has also been associated with other neurological disordes, including serious brain and spinal cord infections. The long-term health consequences of Zika infection are unclear. Other uncertainties surround the incubation period of the virus and how Zika interacts with other viruses that are transmitted by mosquitoes, such as dengue.